Journal: Molecular medicine reports

Article Title: Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice.

doi: 10.3892/mmr.2018.8980

Figure Lengend Snippet: Figure 2. mRNA expression levels of VEGF and MMP‑13 in the knee articular cartilage of mice among the Sham, Dmm and Dmm+Th groups (n=4 in each group). (A) Relative mRNA expression levels of VEGF in the medial articular cartilage. (B) Relative mRNA expression levels of MMP‑13 in the medial articular cartilage. The values are presented as the mean ± standard deviation. *P<0.05 compared with the Sham group; #P<0.05 compared with the Dmm group. Dmm, destabilization of the medial meniscus; MMP‑13, matrix metalloproteinase‑13; Th, thalidomide; VEGF, vascular endothelial growth factor.

Article Snippet: An ELISA kit of VEGF (E-EL-M1292c) was purchased from Elabscience Biotechnology Co., Ltd., Wuhan, China.

Techniques: Expressing, Standard Deviation

Journal: Molecular medicine reports

Article Title: Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice.

doi: 10.3892/mmr.2018.8980

Figure Lengend Snippet: Figure 3. Immunohistochemical analysis of VEGF expression in the knee articular cartilage of mice among the Sham, Dmm and Dmm+Th groups (n=4 in each group). (A) Immunohistochemistry staining of VEGF in the articular cartilage of the medial tibial plateau (magnification, x400, scale bar=100 µm). (B) Quantification of VEGF positive cells, based on the results of immunohistochemistry staining. The values are presented as the mean ± standard deviation. *P<0.05 compared with the Sham group; #P<0.05 compared with the Dmm group. Dmm, destabilization of the medial meniscus; Th, thalidomide; VEGF, vascular endothelial growth factor.

Article Snippet: An ELISA kit of VEGF (E-EL-M1292c) was purchased from Elabscience Biotechnology Co., Ltd., Wuhan, China.

Techniques: Immunohistochemical staining, Expressing, Immunohistochemistry, Staining, Standard Deviation

Journal: Molecular medicine reports

Article Title: Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice.

doi: 10.3892/mmr.2018.8980

Figure Lengend Snippet: Figure 5. ELISA analysis of serum VEGF concentration of mice among the Sham, Dmm and Dmm+Th groups (n=8 in each group). The values are presented as the mean ± standard deviation. *P<0.05 compared with the Sham group; #P<0.05 compared with the Dmm group. Dmm, destabilization of the medial meniscus; Th, thalidomide; VEGF, vascular endothelial growth factor.

Article Snippet: An ELISA kit of VEGF (E-EL-M1292c) was purchased from Elabscience Biotechnology Co., Ltd., Wuhan, China.

Techniques: Enzyme-linked Immunosorbent Assay, Concentration Assay, Standard Deviation

Journal: Experimental and therapeutic medicine

Article Title: Expression and predictive value of HIF-1α and VEGF in patients with burns following treatment.

doi: 10.3892/etm.2020.9270

Figure Lengend Snippet: Figure 1. Changes in serum HIF‑1α and VEGF levels before and after treatment. (A) HIF‑1α decreased significantly following treatment (t=4.983, P<0.001). (B) VEGF significantly increased following treatment (t=8.826, P<0.001). ***P<0.001 vs. before treatment. HIF, hypoxia‑inducible factor; VEGF, vascular endothelial growth factor.

Article Snippet: HIF‐1α ELISA detection kit (cat. no. E‐EL‐H6066) and VEGF ELISA assay kit (cat. no. E‐EL‐H1601c) were purchased from Elabscience Biotechnology Co., Ltd. Moisturizing Burn Cream was obtained from Mebo Pharmaceutical Co., Ltd.

Techniques:

Journal: Experimental and therapeutic medicine

Article Title: Expression and predictive value of HIF-1α and VEGF in patients with burns following treatment.

doi: 10.3892/etm.2020.9270

Figure Lengend Snippet: Figure 2. Predictive value of HIF‑1α and VEGF for treatment efficacy. (A) The level of HIF‑1α in the ineffective group was significantly higher compared with the effective group (t=3.767, P<0.001). (B) VEGF levels in the ineffective group was significantly lower compared with the effective group (t=4.542, P<0.001). ***P<0.001. (C) The AUC of HIF‑1α for treatment efficacy was 0.795, and when the cut‑off point was 161.757, its optimal specificity and sensitivity were 68.75 and 80.88%, and the Youden index was 49.63%. The AUC of VEGF for treatment efficacy was 0.826, and when the cut‑off point was 437.406, the optimal specificity and sensitivity were 68.75 and 82.35% respectively, and the Youden index was 51.10%. While the AUC of the joint detection for treatment efficacy was 0.847, and when the cut‑off point was set as 0.847, the optimal specificity and sensitivity were 87.50 and 66.18% and the Youden index was 53.68%. HIF, hypoxia‑inducible factor; VEGF, vascular endothelial growth factor; AUC, area under the curve.

Article Snippet: HIF‐1α ELISA detection kit (cat. no. E‐EL‐H6066) and VEGF ELISA assay kit (cat. no. E‐EL‐H1601c) were purchased from Elabscience Biotechnology Co., Ltd. Moisturizing Burn Cream was obtained from Mebo Pharmaceutical Co., Ltd.

Techniques: